Conclusion: 2 AAF can induce the overexpression of P gp in rat liver. Intrinsic overexpression of P gp of hepatocellular carcinoma may be ascribed to induction of some carcinogen on the hepatic expression of P gp during the carcinogenesis. 结论:2AAF能够诱导大鼠肝细胞Pgp的过度表达,提示肝癌Pgp天然性过度表达的原因可能与肝细胞癌变过程中,某些致癌物对Pgp的诱导有关。
The study of the combination of kinetics and intrinsic viscosity revealed the copolymerization according with an alternating copolymerization mechanism. The results show that there is not obvious induction period in the copolymerization and reaction goes along evenly till the conversion up to 30%. 聚合动力学研究表明,该共聚几乎没有诱导期,反应初期匀速阶段较长,其转化率接近30%,自动加速不明显。